Aging Skin: Current and Future Therapeutic Strategies – Linda D. Rhein, Joachim W. Fluhr

Aging Skin presents leading-edge strategies to treat problems of aging skin. Current concepts are presented, along with fundamental research detailing the biochemical mechanisms underlying photodamage–the hallmark of aging skin. Based on the premise that aging and senescence occur due to a deterioration of cutaneous repair systems, topics covered include:

• Novel approaches using growth factors that regulate fibrosis to facilitate “cutaneous wound repair” while preventing “solar scar”
• Role of matrix metalloproteinases in the repair of photodamage
• Role of angiogenesis and lymphangiogenesis in response to photodamage and strategies to regulate these processes
• DNA repair and oxidative stress-resistant systems that aid in combating aging skin
• Hormonal influences on skin aging, benefit of hormone replacement therapy and role of nutrition
• Nonenzymatic glycation of matrix proteins due to oxidative stress-altering functionality and strategies to block such untoward reactions
• Success of current treatments–retinoic acid, dermabrasion, Botox, peels and fillers
• Design of the “optimal sunscreen” for prevention of photodamage
• New skin-whitening strategies to reduce age spots by influencing melanogenesis

Allured 2010